論文発表 | 茨城県土浦市 プライムテック株式会社

R&D

R&D/発生工学研究

論文発表

26.  Generation and characterization of RAG2 knockout pigs as animal model for severe combined immunodeficiency.
Suzuki S, Iwamoto M, Hashimoto M, Suzuki M, Nakai M, Fuchimoto D, Sembon S, Eguchi-Ogawa T, Uenishi H, Onishi A.
Vet Immunol Immunopathol. 2016 178; 37-49

25.  Development of Human-Like Advanced Coronary Plaques in Low-Density Lipoprotein Receptor Knockout Pigs and Justification for Statin Treatment Before Formation of Atherosclerotic Plaques.
Li Y, Fuchimoto D, Sudo M, Haruta H, Lin QF, Takayama T, Morita S, Nochi T, Suzuki S, Sembon S, Nakai M, Kojima M, Iwamoto M, Hashimoto M, Yoda S, Kunimoto S, Hiro T, Matsumoto T, Mitsumata M, Sugitani M, Saito S, Hirayama A, Onishi A.
J Am Heart Assoc. 2016 18;5(4)

24.  ピエゾマイクロマニピュレータの特徴と応用
土方彩子
日本臨床エンブリオロジスト学会誌 2014 Vol.16, No.2 1-7,

23.  Growh, Reproductive Performance, Carcass Characteristics and Meat Quality in F1 and F2 Progenies of Somatic Cell-Cloned Pigs
Adachi N, Yamaguchi D, Watanabe A, Miura N, Sunaga S, Oishi H, Hashimoto M, Oishi T, Iwamoto M, Hanada H, Kubo M and Onishi A
Rewproduction and Development 2014 Vol.60, No.2, 100-105

22.  ピエゾマイクロマニピュレータを用いた発生工学技術について
岩元正樹
日本生殖工学会誌 2013; Vol. 16 No. 1: 1-19.

21.  Porcine Model of Hemophilia A
Kashiwakura Y, Mimuro J, Onishi A, Iwamoto M, Madoiwa S, Fuchimoto D, Suzuki S, Suzuki M, Sembon S, Ishiwata A, Yasumoto A, Sakata A, Ohmori T, Hashimoto M, Yazaki S, Sakata Y
PLOS One 2012 7, (11),1-6,

20.  Il2rg Gene-Targeted Severe Combined Immunodeficiency Pigs.
Suzuki S, Iwamoto M, Saito Y, Fuchimoto D, Sembon S, Suzuki M, Mikawa S, Hashimoto M, Aoki Y, Najima Y, Takagi S, Suzuki N, Suzuki E, Kubo M, Mimuro J, Kashiwakura Y, Madoiwa S, Sakata Y, A.C.F. Perry, Ishikawa F and Onishi A.
Cell Stem Cell 2012. 10, 753-758,

19.  Production of cloned pigs expressing human thrombomodulin in endothelial cells.
Yazaki S, Iwamoto M, Onishi A, Miwa Y, Hashimoto M, Oishi T, Suzuki S, Fuchimoto D, Sembon S, Furusawa T, Liu D, Nagasaka T, Kuzuya T, Ogawa H, Yamamoto K, Iwasaki K, Haneda M, Maruyama S and Kobayashi T.
Xenotransplantation. 2012. 19:82-91.

18.  Potential value of human thrombomodulin and DAF expression for coagulation control in pig-to-human xenotransplantation.
Miwa Y, Yamamoto K, Onishi A, Iwamoto M, Yazaki S, Kobayashi T. et al.
Xenotransplantation. 2010. 17:26-37.

17.  Microinjection of serum-starved mitochondria derived from somatic cells affects parthenogenetic development of bovine and murine oocytes.
Takeda K, Tasai M, Akagi S, Matsukawa K, Takahashi S, Iwamoto M, Srirattana K, Onishi A, Tagami T, Nirasawa K, Hanada H, Pinkert CA.
Mitochondrion. 2010. 10:137-42. Epub 2009 Dec 11.

16.  Successful cross-breeding of cloned pigs expressing endo-beta-galactosidase C and human decay accelerating factor.
Yazaki S, Iwamoto M, Onishi A, Miwa Y, Suzuki S, Fuchimoto D, Sembon S, Furusawa T, Hashimoto M, Oishi T, Liu D, Nagasaka T, Kuzuya T, Maruyama S, Ogawa H, Kadomatsu K, Uchida K, Nakao A, Kobayashi T.
Xenotransplantation. 2009 Nov;16(6):511-21.

15.  Relation between human decay-accelerating factor (hDAF) expression in pig cells and inhibition of human serum anti-pig cytotoxicity: value of highly expressed hDAF for xenotransplantation.
Liu D, Kobayashi T, Onishi A. Furusawa T, Iwamoto M, et al.
Xenotransplantation. 14:67-73. 2007

14.  Transmission of mitochondrial DNA in pigs and progeny derived from nuclear transfer of Meishan pig fibroblast cells.
Takeda K, Tasai M, Iwamoto M, Tagami T,Nirasawa K, Hanada H, Onishi A.
Molecular Reproduction and Development. 73: 306-12. 2006

13.  Microinjection of cytoplasm or mitochondria derived from somatic cells affects parthenogenetic development of murine oocytes.
Takeda K, Tasai M, Iwamoto M, Onishi A, Tagami T, Nirasawa K, Hanada H.
Biology of Reproduction. 72: 1397-404. 2005

12.  Effect of caffeine treatment on aged porcine oocytes: parthenogenetic activation ability, chromosome condensation, and development to the blastocyst stage after somatic cell nuclear transfer.
Iwamoto M, Onishi A, Fuchimoto D, Hashimoto M, Hanada H, Nagai T, Kikuchi K.
Zygote. 13: 335-45. 2005

11.  Development to the blastocyst stage of immature pig oocytes arrested before the metaphase-II stage and fertilized in vitro.
Somfai T, Kikuchi K, Onishi A, Iwamoto M, Fuchimoto D, Sato E, Nagai T.
Animal Reproduction Science. 90: 307-28. 2005

10.  Chromosomal instability in the cattle clones derived by somatic cell nuclear-transfer.
Hanada H, Takeda K, Tagami T, Iwamoto M, Fuchimoto D, Onishi A, King WA.
Molecular Reproduction and Development. 71: 36-44. 2005

9.   Low oxygen tension during in vitro maturation of porcine follicular oocytes improves parthenogenetic activation and subsequent development to the blastocyst stage.
Iwamoto M, Onishi A, Fuchimoto D, Takeda K, Hanada H, Nagai T, Kikuchi K, et al.
Theriogenology. 63: 1277-89. 2005

8.   A novel method for the production of transgenic cloned pigs: electroporation -mediated gene transfer to non-cultured cells and subsequent selection with puromycin.
Watanabe S, Iwamoto M, Suzuki S, Fuchimoto D, Nagai T, Hashimoto M, Onishi A, et al.
Biology of Reproduction. 72: 309-15, 2005

7.   体細胞クローンブタ作出効率改善の試み
岩元正樹、菊地和弘、淵本大一郎、永井卓、橋本径子、花田博文、大西彰
日本養豚学会誌. 41: 185-192. 2004

6.   Relationship between the morphological changes of somatic compartment and the kinetics of nuclear and cytoplasmic maturation of oocytes during in vitro maturation of porcine follicular oocytes.
Somfai T, Kikuchi K, Onishi A, Iwamoto M, Fuchimoto D, Papp AB, Sato E and Nagai T.
Molecular Reproduction and Development. 68:484-491. 2004

5.   Effect of replacement of pyruvate /lactate in culture medium with Glucose on preimplantation development of porcine embryos in vitro.
Karja NW, Medvedev S, Onishi A, Fuchimoto D, Iwamoto M, Otoi T and Nagai T .
The journal of Reproduction and Development. 2004 50:587-592.

4.   Advanced in vitro production of pig blastocysts obtained through determining the time for glucose supplementation.
Medvedev S, Onishi A, Fuchimoto D, Iwamoto M and Nagai T.
The Journal of Reproduction and Development. 2004 50: 71-76.

3.   Meiotic arrest maintained by cAMP during the initiation of maturation enhances meiotic potential and developmental competence and reduces polyspermy of IVM/IVF porcine oocytes.
Somfai T, Kikuchi K, Onishi A, Iwamoto M, Fuchimoto D, Papp BA, Sato E and Nagai T.
Zygote. 2003 11: 199-206.

2.   Successful piglet production after transfer of blastocyst production by a modified in virto system.
Kikuchi K, Onishi A, Kashiwazaki N, Iwamoto M, Noguchi J, Kaneko H, Akita T and Nagai T. Biology of Reproduction. 66: 1033-1041. 2002

1.   Pig cloning by microinjection of fetal fibroblast nuclei.
Onishi A, Iwamoto M, Akita T, Mikawa S, Takeda K, Awata T, Hanada H and A. C. F. Perry .
Science. 2000 289:1188-90,

BACK